Multi-voxel MR-spectroscopy signatures and associations with EEG network hyperexcitability and clinical symptomatology in borderline personality disorder
PMC13022906
· 10.3389/fpsyt.2026.1708563
Gap Declaration
Conclusions In summary, while no significant group differences in neurometabolite ratios were observed between BPD patients and HC, our multimodal approach emphasizes the potential of integrating MRSI with EEG to investigate the neurobiology of BPD. Future research employing multimodal approaches is essential to deepen our understanding of the neurobiological underpinnings of BPD. Edited by: Francesca Strappini, Foro Italico University of Rome, Italy Reviewed by: Mahan Shafie, University of Turin, Italy Ibrahim Aslan, University of Southampton, United Kingdom
Abstract
Introduction Previous studies have reported altered gamma-aminobutyric acid (GABA) and glutamate levels in borderline personality disorder (BPD), suggesting disruptions in excitatory-inhibitory neurotransmission. Electroencephalographic (EEG) research has indicated potential network hyperexcitability in BPD, evidenced by increased intermittent rhythmic delta and theta activity (IRDA/IRTA), which may reflect compensatory stabilization mechanisms. This study used multi-voxel magnetic resonance spectroscopic imaging (MRSI) to explore neurochemical abnormalities and their relationships with IRDA/IRTA, psychometric and neuropsychological measures. Methods Sixty-six female patients diagnosed with BPD (mean age: 30.2 ± 9.7 years) and 29 age-matched female healthy controls (mean age: 27.8 ± 8.0 ye…
Conclusions / Discussion
Conclusions In summary, while no significant group differences in neurometabolite ratios were observed between BPD patients and HC, our multimodal approach emphasizes the potential of integrating MRSI with EEG to investigate the neurobiology of BPD. Future research employing multimodal approaches is essential to deepen our understanding of the neurobiological underpinnings of BPD. Edited by: Francesca Strappini, Foro Italico University of Rome, Italy Reviewed by: Mahan Shafie, University of Turin, Italy Ibrahim Aslan, University of Southampton, United Kingdom
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Structural Hole
40% bridge
Technique originates in neuroscience; functional analogues in psychology, criminal justice literature are absent.
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