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A previous study showed that, in 23 adolescents with autism spectrum disorder, increased BLA volume was associated with high reciprocal social interaction scores on the Autism Diagnostic Interview-Revised. The inconsistency between this previous study and our study might be explained by differences in the samples (nonclinical participants with a range of autistic-like traits versus clinically-diagnosed autistic individuals). Nevertheless, both studies have the limitation of small sample size, and thus, future studies with larger sample are warranted to verify the role of the BLA in social cognition. Another possible explanation is that the BLA is heterogeneous complex composed of four different subnuclei (i.e., basal nucleus, lateral nucleus, accessary basal nucleus and paralaminar nucleus), and that the basal nucleus and lateral nucleus might have closer involvement in social information processing. Therefore, there is also a need to further explore correlations of the two subnuclei structure and function with social deficits. [...] Specifically, it has been proposed that distortion is a characteristic of human memory and that some memory errors can be adaptive for flexible behaviors; conversely, overly rigid, robust, and undistorted memory may restrict the modification of thinking and result in low relational binding and behavioral inflexibility. There is evidence from human research that less flexible and less relational retrieval and learning may sometimes cause restricted and repetitive behavior, or, conversely, that inflexible behaviors in autistic individuals may result in rigid and less connected memories. Therefore, the present finding provides a clue that hippocampal CA1, CA3, CA4 and DG are implicated in rigid memory intertwining rigid behavior, suggesting a promising research direction for future studies to advance our understanding of their distinct roles. Finally, across the results, it was somewhat surprising that a single brain region exhibited associations with different subdomains of BAP depending on its structure and function. For example, CA1 volume, but not its functional connectivity, was associated with rigid personality, whereas CA1 functional connectivity, but not its volume, was associated with pragmatic language deficits.
Gateway future studies
Type replication
Section conclusions
Phase 1
Confidence 1.0
Abstract
Prenatal maternal stress (PNMS) increases the risk for autism, and individuals with autism inconsistently exhibit increased or decreased volumes and functional connectivity of the whole amygdala and the whole hippocampus. Given heterogeneous structures of the amygdala and hippocampus and the heterogeneity of autism symptoms, it is worth examining how their subregions contribute to different autism phenotypes. T1-weighted and resting-state functional MRI data were acquired from 32 young adults of mothers who were pregnant during, or within 3 months of, the 1998 Quebec ice storm. Their broad autism phenotype (BAP) was self-reported, including aloof personality, pragmatic language impairment and rigid personality. This sample has a wide range of scores on the BAP Questionnaire. Volumes of the…
Conclusions / Discussion
Discussion This study examined associations between the severity of BAP traits and the volumes and functional connectivity of amygdala nuclei and hippocampal subfields in young adults. All participants in this sample were born following a natural disaster and, while a nonclinical sample, there was considerable variance in the severity of BAP traits which allowed us to uncover correlational associations with amygdala and hippocampal structure and function. Our results demonstrate that it is critical to study the different subdomains of BAP traits separately since we found different patterns in their associations with amygdala and hippocampal volumes and functional connectivity, discussed as below. First, we found no correlations between the overall BAP severity and the volumes and functional connectivity of the amygdala and hippocampal subregions. The lack of association with BLA volume and connectivity echoes previous studies reporting no link between the severity of autism total score and BLA functional connectivity, whereas the severity of one specific subdomain of autism symptoms (e.g., social deficits) was associated with BLA volume and functional connectivity in autistic indiv…
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Does this declaration represent a genuine open research gap?
Structural Hole 40% bridge
Origin psychology
Crossings
criminal justice epidemiology

Technique originates in psychology; functional analogues in criminal justice, epidemiology literature are absent.

NAUGHT — Open Opportunity

No paper has claimed this gap. Appreciate the opportunity.

Provenance
Gap ID57
Paper ID66
PMCIDPMC13039455
AI Check Interrogated — no signals
Detected2026-04-11
Verdict pending
Gap Type replication